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[174] evaluated the effects of different applications of ECT with IV bleomycin (15 IU per m 2 ) in dogs with MCT, being applied as a single therapy trans-surgically, as an adjuvant to surgery, and in recurrent MCTs

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This damage is caused by an increase in intracellular Ca 2+ and an overload of mitochondrial Ca 2+ , which in turn leads to an increase in mitochondrial permeability [106, 123]